Premarin Side Effects

Premarin, created by its parent company Pfizer, is, according to its own website, a drug for the replacement of female hormones, specifically estrogen.

It is most commonly administered to women who are post-menopausal, and have recently completed a hysterectomy.

The drug combats hot flashes and the burning, over-dry and itchy sensations that manifest themselves in the vaginal area in post-operative recovery. Premarin’s side effects, however, place it in a far less therapeutic category of drug.

It is also used as an adjunctive medication to a treatment regimen to restore hormonal balance, and, when used with progestin (a synthetic form of hormonal contraception), it can complete that restoration, claims Pfizer.

As such, it is useful for the treatment of amenorrhea (the lack of menstruation in women who are not post-menopausal, that is, women still capable of reproduction), as well as endometriosis (an intro-uteral cellular growth on the ovaries).   One is referred to the Pfizer website as well as Wikipedia for more information about these conditions and their treatments.

Premarin Side Effects to Women

Premarin side effects have made it a controversial drug ever since Pfizer introduced it.  1975 studies showed a substantial risk of endometrial cancer in women; the drug has a mandated warning label as a result.

Hormone Replacement Therapy studies indicated that the drug increased the risk of strokes, blood clots and embolisms, heart attacks and even breast cancer.

Because of these severe and life-threatening Premarin side effects, the drug is the subject of litigation, not only from patients and families of victims, but because of the methods by which Premarin’s basic chemical compounds are extracted.

Number trials are on the docket at the moment not only from the participants in the medication’s usage, but also by animal cruelty experts.

Premarin, as its own website will disclose, is extracted from the urine of a female horse, and many animal handlers protest what they see as a cruel treatment of the mares in extracting their urine forcibly.

The company responds, somewhat perfunctorily, that every safeguard is in place for the horses, and the extraction methods must be extensive to keep up with demands.

Between this litigious Scylla and Charybdis, Pfizer finds itself with little wiggle room.   Its sub-branch, Wyeth enterprises, which takes direct responsibility for manufacturing the drug, was confronted with the long term findings of the HRT committee, and could only reply that “over 99 percent of the women took the drug and did not get breast cancer.”

If you would like further information about Premarin and/or any of these other substances, or if you have been involved in a Premarin treatment program and have experienced ill effects personally, you should immediately consult your health professional, and get in touch with a drug lawyer at the American Bar Association, online at (read about how to hire a drug injury attorney)